Sabine Kolczewski : rechercher sur Z-Library

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1

ChemInform Abstract: Structure—Activity Relationships of Substituted 5H-Thiazolo[3,2-a]pyrimidines as Group 2 Metabotropic Glutamate Receptor Antagonists.

Juergen Wichmann, Geo Adam, Sabine Kolczewski, Vincent Mutel, Thomas Woltering

Journal:

Année:

1999

Fichier:

PDF, 31 KB

1999

2

ChemInform Abstract: Synthesis of Heterocyclic Enol Ethers and Their Use as Group 2 Metabotropic Glutamate Receptor Antagonists.

Sabine Kolczewski, Geo Adam, Heinz Stadler, Vincent Mutel, Juergen Wichmann, Thomas Woltering

Journal:

Année:

1999

Fichier:

PDF, 29 KB

1999

3

ChemInform Abstract: Stereoselective Deprotonation of Chiral and Achiral 2-Aminoalkyl Carbamates: Synthesis of Optically Active β-Amino Alcohols via 1-Oxy-Substituted Alkyllithium Intermediates.

Joerg Schwerdtfeger, Sabine Kolczewski, Berthold Weber, Roland Froehlich, Dieter Hoppe

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 44 KB

english, 1999

4

Parallel Solution- and Solid-Phase Synthesis of Spirohydantoin Derivatives as Neurokinin-1 Receptor Ligands.

Konrad H. Bleicher, Yves Wuethrich, Maxime De Boni, Sabine Kolczewski, Torsten Hoffmann, Andrew J. Sleight

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 101 KB

english, 2003

5

Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series

Simona M. Ceccarelli, Götz Schlotterbeck, Patrick Boissin, Martin Binder, Bernd Buettelmann, Steven Hanlon, Georg Jaeschke, Sabine Kolczewski, Ernst Kupfer, Jens-Uwe Peters, Richard H. P. Porter, Eric

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 448 KB

english, 2008

6

Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)-2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid—HYDIA

Thomas J. Woltering, Geo Adam, Philipp Huguenin, Jürgen Wichmann, Sabine Kolczewski, Silvia Gatti, Anne Bourson, James N. C. Kew, Grayson Richards, John A. Kemp, Vincent Mutel, Frédéric Knoflach

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 584 KB

english, 2008

7

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration

Jens-Uwe Peters, Thomas Lübbers, Alexander Alanine, Sabine Kolczewski, Francesca Blasco, Lucinda Steward

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 189 KB

english, 2008

8

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Bernd Büttelmann, Jens-Uwe Peters, Simona Ceccarelli, Sabine Kolczewski, Eric Vieira, Eric P. Prinssen, Will Spooren, Franz Schuler, Jörg Huwyler, Richard H.P. Porter, Georg Jaeschke

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 170 KB

english, 2006

9

Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure

Simona M. Ceccarelli, Georg Jaeschke, Bernd Buettelmann, Jörg Huwyler, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Richard Porter, Will Spooren, Eric Vieira

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 172 KB

english, 2007

10

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation

Jens-Uwe Peters, Thomas Lübbers, Alexander Alanine, Sabine Kolczewski, Francesca Blasco, Lucinda Steward

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 155 KB

english, 2008

11

Parallel solution- and solid-Phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands

Konrad H. Bleicher, Yves Wüthrich, Maxime De Boni, Sabine Kolczewski, Torsten Hoffmann, Andrew J. Sleight

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 130 KB

english, 2002

12

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

Jürgen Wichmann, Geo Adam, Sabine Kolczewski, Vincent Mutel, Thomas Woltering

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 180 KB

english, 1999

13

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists

Sabine Kolczewski, Geo Adam, Heinz Stadler, Vincent Mutel, Jürgen Wichmann, Thomas Woltering

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 162 KB

english, 1999

14

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists

Georg Jaeschke, Richard Porter, Bernd Büttelmann, Simona M. Ceccarelli, Wolfgang Guba, Bernd Kuhn, Sabine Kolczewski, Jörg Huwyler, Vincent Mutel, Jens-Uwe Peters, Theresa Ballard, Eric Prinssen, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 206 KB

english, 2007

15

Spiroforskolin: Structure and mode of formation

Sabine Kolczewski, Rita Rosenbaum, Petra Wagner, Peter Welzer

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 809 KB

english, 1992

16

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors

Pinard, Emmanuel, Alberati, Daniela, Alvarez-Sanchez, Ruben, Brom, Virginie, Burner, Serge, Fischer, Holger, Hauser, Nicole, Kolczewski, Sabine, Lengyel, Judith, Mory, Roland, Saladin, Christian, Schu

Journal:

ACS Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 915 KB

english, 2014

17

Novel Hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4- c ]pyrroles]: Highly Selective Small-Molecule Nociceptin/Orphanin FQ Receptor Agonists

Kolczewski, Sabine, Adam, Geo, Cesura, Andrea M., Jenck, François, Hennig, Michael, Oberhauser, Thomas, Poli, Sonia M., Rössler, Felix, Röver, Stephan, Wichmann, Jürgen, Dautzenberg, Frank M.

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 169 KB

english, 2003

18

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1 H -imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk,

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2015

19

New short access to pyrrolo[2,3-c]pyridazin-6-ones via β-spirolactams

Stoll, Theodor, Alker, André, Kolczewski, Sabine, Menzi, Andrea, Revil-Baudard, Vincent

Journal:

Tetrahedron Letters

Année:

2015

Langue:

english

Fichier:

PDF, 603 KB

english, 2015

20

Functional heterogeneity of nociceptin/orphanin FQ receptors revealed by (+)-5a Compound and Ro 64-6198 in rat periaqueductal grey slices

Liao, Yan-Yu, Teng, Shu-Fang, Lin, Li-Chun, Kolczewski, Sabine, Prinssen, Eric P., Lee, Li-Jen, Ho, Ing-Kang, Chiou, Lih-Chu

Journal:

The International Journal of Neuropsychopharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 423 KB

english, 2011